J.Jpn. Surg. Soc.. 78(12): 1151-1164, 1977

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Original article

IMMUNOLOGICAL STUDIES IN CHRONIC OCCLUSIVE ARTERIAL DISEASES

Immunological studies were performed on 19 patients with aortitis syndrome, 36 patients with Buerger's disease (TAO) and 29 patients with arteriosclerosis obliterans (ASO). Serum protein components were analysed by single radioal immunodiffusion and crossed immunoelectrophoresis. The following results were obtained.
1. Increase of α₁ antitrypsin (α₁AT) and haptoglobin (Hp) were definite in all three diseases, which changed in relation with various stages of the disease .
2. Increase of total fractions of serum protein was prominent and persisted during active stage of aortitis, while no abnormality were present in inactive stage.
3. Moderate increase of α₁ AT and Hp was characteristic in both TAO and ASO, especially where ischemic ulcer was present in the peripheral part. Increse of total fractions of serum protein was rarely found in these diseases.
4. Increase of α₁AT, Hp. Hemopexin (Hx), β₁/β_1A globulin (C3) and C3 activator was significant in aortitis compared to control. Hp, Hx and C3 were significantly raised compared to TAO, and Hp, Hx. Trasferrin (Tf) and C3 compared to ASO.
5. C3, C4 and C3 activator were significantly raised in acute stage of aortitis while within normal limits in TAO and ASO.
6. High incidence of negative tuberculin test was found in aortitis suggesting of decreased cell -mediated immunity, while very low in TAO and ASO.

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