J.Jpn. Surg. Soc.. 78(11): 1069-1080, 1977

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Original article

EXPERIMENTAL CHEMOTHERAPY OF CARCINOMAS OF THE HUMAN STOMACH AND COLON SERIALLY TRANSPLANTED IN NUDE MICE

Human gastric carcinomas (St-4 and St-15) and a colon carcinoma (Co-3) serially transplanted in nude mice with a BALB/c genetic back ground, were used for chemotherapeutic experiments. All tumors showed 100% take-rate and stable growth.
Mitomycin C (MMC), 3 mg/kg body weight given intraperitoneally 4 times once weekly, showed some inhibiting effects on Co-3, St-15 and St-4, in that order. N₁-(2'-tetrahydrofuryl)-5-Fluorouracil (FT-207), 90 mg/kg body weight intraperitoneally daily for 4 weeks suppressed the growth of Co-3 and St-15 slightly but with statistical significances, and had no effect on St-4. Co-3, a tumor with more rapid growth and richer vascular supply was suppressed more by MMC and FT-207. The growth of St-4 was not affected by PS-K, which is a protein-bound polysaccharide isolated from basidiomycetes and was known to possess a host-mediated antitumor activity.
These three transplantable tumors were found to be excellent materials in evaluating chemotherapeutic agents for use against human gastrointestinal carcinomas.

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