J.Jpn. Surg. Soc.. 78(11): 1062-1068, 1977
Original article
DEVELOPMENT OF DISSEMINATED INTRAVASCULAR COAGULATION (DIC) FOLLOWING INCOMPATIBLE BLOOD TRANSFUSION: PROPHYLACTIC USE OF HEPARIN
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Department of Surgery Ⅰ, Kyushu University Faculty of Medicine, Fukuoka Keiichi Ohsato, Akira Takaki, Shigeaki Takeda |
Six patients who received incompatible blood transfusions are reported. In one, a generalized bleeding diathesis and acute renal failure developed with laboratory findings characteristic in disseminated intravascular coagulation (DIC). The antibody responsible for the incompatibility was an anti-E. In other five patients received mismatched transfusions due to ABO group incompatibility, administration of heparin was started as soon as possible after the accident to prevent severe transfusion reactions due to DIC. All were symptomatically uneventful, however, an elevation of FDP and thrombocytopenia were noted in one and moderate increase of blood urea nitrogen in three in their clinical course. These findings seem to represent the subclinical participation of clotting episodes in mismatched transfusion reactions, even after the heparin administration. Hence, occurrence of DIC may be more frequent than had been appreciated and prompt treatment with heparin prior to the recognition of signs and symptoms may decrease the morbidity and mortality from incompatible transfuaion reactions.
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