J.Jpn. Surg. Soc.. 62(11): 1200-1214, 1961

---

THE HISTOPATHOLOGICAL STUDIES OF THE GASTRIC MYENTERIC PLEXUS OF IDIOPATHIC CHRONIC GASTRITIS AND ATTENDANT CHRONIC GASTRITIS IN GASTRODUODENAL ULCER

The resected specimens of the stomach of the 79 cases with the gastro-duodenal ulcer and the idiopathic chronic gastritis were examined for these histophthological studies. The materials were stained by the Bielschowsky-Ide's silver, hematoxylin-eosin and Nissle's thionin stainning.
From pathological changes of the nucleus of the ganglion cell, the author divided into five degrees. According to quantitative degenerative severity of the ganglion cell the author determined the ratio of the ganglion cell which have heavy nucleal degeneration to the total ganglion cells of the plexus. The results obtained were as follows :
1) The cause of the degeneration of the myenteric ganglion celis are secondary due to the mucosal inflammatory process of the chronic gastritis.
The ratio of the ganglion cell which have heavy nucleal degeneration to the total ganglion cells of the plexus is closely connected with the type of the mucosal inflammatory atrophic changes.
2) The pathological changes of the ganglion cells in the myenteric plexus reveal more obvious, while the gastric mucosal inflammatory atrophic changes increase.
However, in some cases, the degenerative changes of the ganglion cells are considered to be progressed due to the irritation of the autonomic nervous system itself, and are supposed to have no relation with the mucosal pathologic findings.
3) In the idiopathic chronic gastritis, with a view of degenerative changes of the ganglion cell, there are more cases of the antrum gastritis than other type of gastritis and most cases of the diffuse gastritis are supposed to be developed secondary from the antrum gastritis.
4) Preoperative clinical manifestations are influenced mostly by the mucosal inflammatory atrophic changes, but partially by the degenerative changes of the ganglion cells. Some cases, which have slight mucosal inflammatory atrophic changes, show heavy degenerative changes of the ganglion cells and complain severe epigastric pain.
5) In the gastro-duodenal ulcer, the degenerative changes of the ganglion cells are heavier than the idiopathic chronic gastritis compairing with the mucosal inflammatory atrophic changes. These studies have revealed that in the gastro-duodenal ulcer the ganglion cells in the myenteric plexus are supposed to be influenced not only by the gastric mucosal inflammation but also by the degenerated nervous plexus in the tissue beneath the ulcerous portion.
(Author's abstract)

---

---

To read the PDF file you will need Adobe Reader installed on your computer.