J.Jpn. Surg. Soc.
ISSN 1880-1129

[Abstract] [Full Text PDF] （in Japanese / 10089KB） [Members Only And Two Factor Auth.]

J.Jpn. Surg. Soc.. 62(10): 1091-1104, 1961

STUDIES ON THE EFFECTS OF BARBITURATE, CHLORPROMAZINE AND INHALATION ANESTHESIA ON PLASMA LEVELS OF 17-HYDROXYCORTICOSTEROIDS.

Surgical Department, Keio Gijuku University School of Medicine (Director: Prof. Nobukatsu SHIMADA)

Junichiro KIKUCHI

The effects of tranquilizing agents such as barbiturate and chlorpromazine, and general inhalation anesthesia (ether and nitrous oxide) on pituitary adrenocortical axis were studied in 34 surgical cases and in 43 dogs, by measuring 17-hydroxycorticosteroids (17-OHCS) in the peripheral circulating blood usimg Silber -Porter's method (1954). Concentrations of 17-OHCS at 8.00 a.m. on the day just before operation were higher than those of normal subjects reported previously by us (1957). It might be thought that psychic tension against operation became a mild adreno-cortical stimulation. Although greater elevations of plasma 17-OHCS were expected on the day of operation, there were no changes in most cases. It might be considered that barbiturate and chlorpromazine administered as premedication modified the secretory activity of the adrenal cortex.
When stressors such as fixation and simple laparotomy were applied, the dogs having barbiturate and chlorpromazine infusion for a period up to 2 or 3 hours showed less elevations of 17-OHCS than the controls. Especially, inhibitory actions of chlorpromazine on corticosteroid secretion were remarkable. In clinical observations inhalation of ether and nitrous oxide produced significant elevations of plasma 17-OHCS and it was observed that the former was more potent in activating the adrenal cortex. However, these actions of anesthetics were also inhibited by barbiturate and chlorpromazine. It was confirmed that the reduction of 17-OHCS concentrations described above was due to the secondary inactivation resulting from the supression of ACTH release from the pituitary gland following administration of barbiturate and chlorpromazine, because dogs treated with tranquilizing agents showed significant increases of corticosteroids secretion when ACTH was infused.
(Author's abstract)

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