J.Jpn. Surg. Soc.. 62(7): 722-731, 1961
LIVER FUNCTION IN GASTRIC CANCER SECOND REPORT POSTOPERATIVE CHANGES
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Prof. M. Muto's Surgical Clinic, Tohoku University, Sendai Kazuhiko INOUE |
1. Liver functions were tested on the 3rd, 7th and 21st days after operatoin, in 62 and 19 cases which had been gastrectomized for gastric cancer and for gastric or duodenal ulcer respectively, with the following results.
1) Through all the cases a transient aggravation of the liver function was observed 3 to 7 days after operation, then it tended to recover.
2) In cancer cases, the recovery of the liver function from the postoperative aggravation was much more retarded than in the ulcer cases, these two groups showing an evident difference in the liver function even at the time of discharge (21 days after operation) .
3) These postoperative changes in the liver function were proved to be due mainly to the surgical invasion or to the various postoperative managements. The true effect of the extirpation of the tumor could not be detected in this period.
2. Sixty cases of gastric cancer and 29 cases of gastric or duodenal ulcer were also studied 7 to 10 months after gastrectomy, for obtaining the remote results. The results are as follows.
1) In both the groups, the liver function was generally worse as compared with the respective preoperative state. This was thought to be a manifestation of the so-called agastric syndrome.
2) When the cancer group and ulcer group were compared with each other, however, the former showed the more marked impairment of the liver function.
3) Cases with the clinical evidende of the cancer recurrence showed more severe disturbances in the liver function than the others. In addition, no correlation was observed, in contrast to the preoperative case, between the grade of the hapatic impairment and the extent of the cancer spread at the time of operation. These facts suggest that the impairment of the liver function in gastric cancer is a phenomenon elicited from the existence and spread of the tumor and can be repaired, at least in a theoretical sense, bv extirpation of the tumor. (Author 's abstract)
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