J.Jpn. Surg. Soc.. 62(2): 224-239, 1961
SERUM PROTEIN IN GASTRIC CANCER WITH SPECIAL REFERENCE TO THE RELATION WITH CANCER PROGRESS AND POSTOPERATIVE CHANGES
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Prof. M. Muto's Surgical Clinic, Tohoku University, Sendai Yasushi NISHIYAMA |
Further, similar examinations were performed 7 to 10 months after gastrectomy in 73 cancer and in 40 ulcer cases.
A. Preoperative results
1) In gastric cancer cases, the total concentration of serum protein was lower than in the control cases or the healthy adults, there being observed a remarkable loss of albumin, compensatory increase in α-globulin, slight increase in, β-and γ-globulins, and lowering of the albumin-globulin ratio.
2) These changes in serum proteins were more obvious in cases with the more advanced peritoneal dissemination and in those with the more extensively involved lymph nodes, that is, these were dependent upon the progress of the lesion.
However, early cancer cases presenting neither dissemination nor metastasis showed also perceptible changes in serum proteins.
3) The mentioned changes in serum proteins were more evident in cases with the larger tumors, but not correlated with other gross appearances of the tumor nor with the histological features of the cancer tissue.
B. Results three weeks after operation
Though the figures of serum proteins were various from case to case presumably owing to the operative invasions or to such postoperative treatments as the blood transfusion, administration of protein preparations and others, the decrease in albumin and the increase in α-globulin were more marked in cancer cases, even in this period, as compared with the controls.
C. Results 7 to 10 months after gastrectomy
1) In this period, the control cases which had been operated for peptic ulcer showed some specific changes in serum proteins, the characteristic figures of which showed a marked increase in α-and γ-globulins. This was thought to be a manifestation of the so-called postgastrectomy syndrome which is common to the cases gastrectomized, either for benign diseases or for malignancies.
2) Even considering the common postoperative changes mentioned above, the figures of serum proteins were apparently abnormal in cases with the cancer recurrence, albumin being markedly decreased and α-globulin increased.
3) Cases without any signs suggesting the cancer recurrence showed far improved protein figures as compared with the preoperative state. But, when compared with the control cases in the same stadium of the postoperative course, some abnormalities were still observed in them, mainly consisting of a decrease in albumin and an increase in α-globulin.
These abnormal figures were particularly marked in those in which the cancer spread had been remarkable at the time of the operation or in those with the evident loss of body weight during the postoperative course.
(Author's abstract)
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