J.Jpn. Surg. Soc.. 62(1): 1-15, 1961
CHANGES IN THE PLASMA AND TISSUE PROTEIN INDUCED BY ILEUS SHOCK : REPORT I.
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Department of Surgery, Nihon Medical School (Director: Prof. Saburo MATSUKURA) Kiyoshi OKAZAKI |
l . 1) A marked reduction occurs in the amount of plasma protein during the appearance of ileus shock. Concomitant with this change, the hematocrit value and hemoglobin content of the blood show a remarkable rise.
2) Although no significant changes are recognizable in the blood of either femoral or portal vein at the tim of ileus shock, the water content of the venous blood of the liver is evidently decreased. this means that a striking hemoconcentration is induced by ileus shock, and with it there occurs a marked diminution in the plasma protein content.
ll . 1) The level of serum protein is low in the blood of both femoral and portal veins, but hepatic venous blood shows no significant changes due to ileus shock.
2) The concentration of serum albumin is reduced during ileus shock in the blood of the femoral and portal veins, while no notice able changes occur in the blood of hepatic vein.
3) At the time of ileus shock, no remarkable changes are seen in the concentration of serum globulin in the blood of either femoral of portal vein. This implies also that α, β and γ fractions of serum globulin are practically unchanged.
These observations prove that during ileus shock the concentration of serum proteins, particularly that of albumin is reduced in blood of both the femoral and portal veins, while there is no segoificant changes in blood of the hepatic vein.
III . The volumes of circulating blood, plasma and erythrocytes are also reduced remarkably with the progress of ileus shock. Approximatly the reduction in the volume of circulating blood and of plasma in ileus shock amounts to approximately half of the normal values.
IV . 1) The amount of stored proteins the liver is definitely higher than that of conjugated proteins under normal conditions. However, since this relation is reversed in the muscle tissue, it is assumed that it is the protein stored in the liver, which is directly responsible for the changes in plasma proteins.
2) A marked reducion occurs in the total protein content of the liver, especially that of stored proteins, during ileus shock. This fact well agrees with the foregoing observation that in ileus shock no significant changes are racognizable in the concentration of serum proteins, particularly of serum albumin, in the hepatic venous blood, while the level is low in blood of both the femeral and portal veins.
V. At the time of ileus shock, in contrast to decreased water content of the muscle tissue, it is clearly increased in the liver. This fact is in good agreement with above finding that, in ileus shock, while no remarkable variations are noted in the water content of the blood of both the femoral and portal veins, the hepatic venous blood shows a decided reduction.
(Author's abstract)
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