J.Jpn. Surg. Soc.. 61(4): 576-588, 1960

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STUDY ON A DEFENSIVE ACTION IN INTESTINAL TISSUE FOR INFECTION

In our daily surgical operations on the stomach, digestive canal, anus and vagina, wound infections such as by defective suture, are seldom encountered in spite of many existing bacteria in these tissues.
With the assumption that there might be some anti-infectional materials in these tissues, I have conducted the present study with special reference to the intestinal canal.
1) The most powerful agent to retard the development of these bacteria was demonstrated in the extract of mucous membrane of the intestinal canal of men and adult dogs .
2) The extract is an enzyme-like substance in which hydrolytic nuclearic acid disintegration is most remarkable. The lysophilized extract is most suitable, which differs from lysozyme but resembles ribonuclease.
3) In appendicitis, these activities increase first in the stage of phlegmonous, and secondly of catarrhal inflammations, while they decrease in the stage of necrotic inflammation, and furthermore, in the stage of intestinal obstruction.
No special changes were recognized in relation to the use of antibiotics.
(Author's abstract)

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