J.Jpn. Surg. Soc.. 61(3): 370-386, 1960

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HISTOCHEMICAL STUDIES ON GASTRIC ACIDITY (INTERRELATION BETWEEN GASTRIC ACIDITY AND METAPLASIA OF THE INTESTINAL EPITHELIUM ON THE GASTRIC MUCOSA) .

The author investigated the question as to what effect intestinal metaplasia exerts on gastric acidity in diseased stomachs, using as materials total of 150 cases, including 70 cases of stomach cancer, 58 of gastroduodenal ulcer and 22 of chronic gastritis.
Metaplasia of the intestinal epithelium (goblet cells) is frequently encountered on the wall of stomach cancer and found at the pyloric region in the frequency order of chronic gastritis and gastroduodenal ulcers.
Histochemically the secreted material is a buffer secretion, at pH 6.4 • 6.9, containing mucopolysaccharide or mucoprotein combined with acids. It is not merely a neutalizer of acid.
Organic chlorides of gastric juice in cases with positive goblet cells show usually high values.
Upon pursuing the relation of gastric acidity to goblet cells and pariental cells, there are many intances of either anacidity or hypoacidity when goblet cells are present, showing no parallelism between gastric acidity and the number of parietal cells. On the contary, when no goblet cells are present, gastric acidity reveals a parallelism with the parietal cells.
(Author's Abstract)

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