J.Jpn. Surg. Soc.. 61(1): 12-28, 1960
STUDIES ON HOMOLOGOUS SKIN TRANSPLANTATION
Ⅱ. ON THE SO-CALLED ACTIVELY ACQUIRED TOLERANCE
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Department of Surgery, Facully of Medicine, Tohoku Universty, Sendai. (Director: Prof. S-T. KATSURA) Sakari SATO |
1. The graft survived for 24.4 days on the average when transplanted to mice of 4-5 weeks after birth used as controls. This is longer than the mean survival time in the control experiments reported in the part I. of this series, and may be attributed to the immaturity of the subjects.
2. When new-born mice of dd-strain 8-24 hours after birth are injected subcutaneously with spleen cell suspension, whole blood or whole blood-cell suspension from C57BL-strain mice and 4-5 weeks afterwards, skin was transplanted from the latter, the graft survived for a long time in high frequency, hairs in the color proper to the donor being observed growing on the graft in many cases. But permanent acceleration could not be realized, the longest time of survival being 52 weeks.
3. The effective factor producing long survival in the whole blood abides in its leucocytes.
4. The crude polysaccharide fractions extracted from the skin or the spleen exhibited no such an effect in pr olonging the life of the graft.
5. This effect has a strain or individual specificity.
6. Similar injections applied in the second or third week after the recipients' birth were effective only in a lower degree.
7. Previous general X-ray irradiation applied to the recipient enhanced the effect even in the case where the injection had been delayed.
8. The live grafts were gradually atrophied and absorbed after a length of time. Even in the case where the cellular injection proved efficacious, infiltration of round cells, chiefly lymphocytic cells, was always observable. The hair follicles were kept intact over long periods in many cases.
(Author 's abstract)
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