J.Jpn. Surg. Soc.. 60(14): 2164-2174, 1960

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AN EXPERIMENTAL STUDY OF THE DISTRIBUTION OF THE RADIOISOTOPES IN THE ANIMALS, ESPECIALLY WHEN THEY ARE GIVEN THROUGH THE TRACHEA.

While the problem of the invasion and contamination of the radioactive substance through the airway is attended, it has been considered as extremely difficult, to examine into closely experimentally.
Concerning this point, a new method was planned and an experiment was made, to make a complete tracheal fistula and introduce some radioactive substance through the fistula, excluding other invading courses, that is, of percutaneous or oral contamination.
Namely, after making a comlpete tracbeal fistula on the neck of the rabbit, some amount of radioactive phosphorus P³², radioactive strontium Sr⁸⁹ and fission products were introduced through the fistula.
The result was obtained, that a great amount of radioactive phosphorus P³² was distributed in the skeleton, liver and musele, and absorbtion of this eIement was more rapid when given through the tracheal fistula, than oral and intramuscular gavage and that the greatest amount of radioactive strontium Sr⁸⁹ were distributed in the skeleton when given through the tracheal fistula, and most amount of fission products was distributed in the skeleton and a little in th soft tissue by each gavage.
By this experiment, it was proved that P³² Sr⁸⁹ and other fission products were absorbed through the alveolar wall, and pointed ont that it was possible that moderate amout of radioactive substances invaded into the body through the airway.
(Author's abstract)

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