J.Jpn. Surg. Soc.. 60(10): 1617-1635, 1959
CLINICAL AND EXPERIMENTAL STUDIES ON ANAPHYLACTOID REACTIONS DUE TO ADMINISTRATION OF PENICILLIN
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Surgical Department, Kanto Teishin Hospital (Director: Dr. S. Ishiyama) Morio TAKEDA |
The clinical signs of anaphylactoid reactions due to administration of penicillin consisted of symptoms of respiratory, cardiovascular and central nervous systems, which were identificially demonstrated in the analysis of 11 patients who showed anaphylactoid reactions after administration of penicillin.
Irritability of autonomic nervous system, Thorn's-test and fibrinolysis were tested in 4 cases of 11 shock patients.
It is clear that they had dispositions for shock. The results of the skin-test using inactivated penicillin were almost the same as that of active penicillin. The skin-test in patients with allergic histories like asthma or urticaria due to foods, showed positive results in higher incidence than that in the patients without any allergic histories.
The skin-test in the patients who have previously received penicillin, were positive in higher percentage than in the patients who have never received it.
The results of experimental sensitisation to gineapigs with penicillin, inactivated penicillin and decompositions of penicillin were also demonstrated.
Schultz-Dale test showed the establishment of sensitisation in the groups which were treated with penicillin and with inactivated penicillin, while any positive results were not observed in the groups which were treated with the decompositions of penicillin. Serum affinities of penicillin and other antibiotics, namely, streptomycin, chloromycetin. albamycin, achromycin, were studied by means of dialysis method.
Serum affinities of penicillin G and penicillin V were stronger than the other antibiotiotics.
Ii was demonstrated in the dialysis using the radio-active penicillin that the penicillin bounded with serum losted its antibacterial activities.
We concluded in our present investigations as the inactivated penicillin played an important role in the establishment of anaphylactoid reactions due to penicillin.
(Author's abstract)
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