J.Jpn. Surg. Soc.. 60(10): 1535-1548, 1959
THE METABOLISM OF TRYPROPHAN IN PORTACAVAL ANASTOMOSIS, STUDIED IN THE HUMAN SUBJECT AND THE DOG
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Second Department of Surgery, Nagoya University School of Medicine (Director: Prof. Hajime IMANAGA) Yoshimori TANAKA |
The urine was collected for 24 hours and was treated in order to identify tryptophan metabolites and to enable semi-quantitative estimation, To isolate the tryptophan metabolites, the paper-chromatographic method of Dalgliesh was used.
The influence of administration of histidine, riboflavin and pyridoxine upon the tryptophan metabolism was observed.
1. They showed, after anastomosis, a small amount of the fed tryptophan passes liver and an extremely large amount of urinally excreted tryptophan did not passed the liver.
The metabolism of tryptophan passed the liver was controlled by the degree of that liver function in human beings.
2. After anastomosis, in man, a considerable degree of the fed L-tryptophan was converted to Nα-acetyl-L-tryptophan in vivo.
3. If liver function is very poor, there is no effect of histidine, riboflavin and pyrioxine upon the tryptophan metabolism in human subjects.
4. It was found that 3-hydroxykynurenine was excreted in the urine easily in all dog cases after ingestion of 300 mg. of L-tryptophan per kg. of body weight. This excretion has no particular correlation to normal controls, dogs after portacaval anastomosis and administration of pyridoxine.
(Author's abstract)
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