J.Jpn. Surg. Soc.. 60(7): 1140-1159, 1959

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THE CLINICAL AND HISTOLOGICAL STUDIES ON CHEMOTHERAPY OF MALIGNANT TUMOR OF LYMPHNODE

Fourty-two cases of malignant tumor of lymphnode were treated each with single administration of nitrogen mustard N-oxide (Nitromin), Thio-TEPA, Actinomycin J, Mitomycin C and ED virus. Decrease in size of the tumor was observed in 15 of 24 cases which were treated with nitrogen mustard N-oxide, 8 of 10 cases treated with Thio-TEP A, 6 of 11 cases treated with Actinomycin J, 2 of 3 cases treated with Mitomycin C and 1 of 2 cases treated with ED virus.
The exploratory excision and the histological study of malignant tumor of lymphnode were performed before the treatment in every case and after the treatment in 25 cases. The histological findings were arranged by Lumb's classification. The histological findings of post-treatment cases were compared with that of pre-treatment cases and effects of the anti-cancer drugs were criticized. Histologically, the anti-cancer drugs were appeared to be effective in 13 of 25 cases. Degeneration and necrosis of tumor cells, infiltration of inflammatory cells and stromal fibrosis were recognized to be the main histological changes caused by the anti-cancer drugs. The histological findings of each malignant tumor of lymphnode in post-treatment cases were varied admixture of the above histological findings, but generally were classified into the following three types:
1) Degenerated tumor cells were diffusely scattered without fibrosis in the tumor.
2) Degenerated tumor cells were diffusely scattered with dense fibrosed stroma in the tumor.
3) Localized foci of degenerated tumor cells aggregates were remained in the dense fibrosis.
Their histological changes were not characterized by each anti-cancer drug.
(author's abstract)

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