J.Jpn. Surg. Soc.. 60(6): 962-980, 1959
EXPERIMENTAL STUDIES OF BRAIN COOLING IN THE FIELD OF NEUROSURGERY. (BRAIN TISSNE CHANGES AT ULTRAHYPOTHERMIA AND EXPERIMENTAL STUDIES OF BRAIN OPERATION BY MEANS OF SELECTIVE BRAIN COOLING)
|
1st Surgical Department, Tokyo University School of Medicine (Director: Prof. Kentaro SHIMIZU) Fumihiko HAYASHI |
The following results were obtained from these experiments :
1) The upper limit of temperature which causes irreversibl changes in th bra in tissue under local cooling seemed to be at 7°~8°C. However, if cooled for a longer period of time, changes in the parenchyma, vessels or nerve cells of the brain described above may be caused at the temperature of 7°~15°C.
2) The method of blood cooling, in which cooling needles were inserted in th bilateral common carotid arteries, diminished temperature of the brain cortex by only 1.2°~3°C after application longer than 1 hour. Therefare, this method alone does not seem to be clinically applicable.
3) In the experimental br in operations with selective brain irrigation cooling, arrest in the cerebral blood flow for 20~25 minutes, which is necessary for operative procedures, could be obtained without brain tissue damage at the temperature of 20 ~ 22 °C .
Fifteen percent of the operated cases survived postoperatively, the rest (75%) died with postoperative bleeding.
This postoperative bleeding, which is fatal to brain operations even if in a small amount, can be reduced by finding more adequate anti-heparin substances or inproving the method of hemostasis of the brain tissue. If these problems were solved, the brain operations which have been considered impossible so far may be more safely performed by the aid of this brain cooling method compared with other methods.
(author's abstract)
To read the PDF file you will need Adobe Reader installed on your computer.