J.Jpn. Surg. Soc.. 60(6): 930-943, 1959
A STUDY ON N.P.N. IN THE EXUDATE FROM EXPERIMENTALLY-PRODUCED FOCI OF INFLAMMATION
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Department of Surgery, Keio Gijuku University School of Medicine (Director: Prof. N. Shimada) Kazumi MIZUNO |
The results of the study were as follows :
1) When admistering penicillin in suppurative bacterial inflammation, one should determine the mode of its administration by considering the time from the onset of the disease as well as its causative organism. It was noted that while relatively smaller doses were needed in the early stage of the disease, larger doses were required as time elapsed.
2) The amount of N.P.N. in the exudate from the inflammatory foci varied according to the type of causative organism, the course of the disease, and whether penicillin had been used or not.
3) Measuring N.P.N. at certain intervals following penicillin would indicate its efficacy.
4) PH of the exudate in the two groups, the foreign-body reaction (plastic ball only) and bacterial inflammation (plastic ball with staphylococcal injection) is acid and it was not significantly affected by penicillin administration.
5) Protein in the exudate varied between 3.5 and 4.5%. There was a differenc between the foreign-body reaction and the bacterial inflammation, with greater changes and also greater effects of penicillin administration in the latter group.
6) In the cellular composition of the exudate, monocytes and lymphocytes markedly increased after penicillin while highly degenerated cells varied markedly only in the bacterial inflammation group.
7) Serum N.P.N. of the normal rabbits ranged between 25 and 49 mg/dl, with highest incidence at 32.5 mg/dl.
8) Serum N.P.N. of rabbits with experimentally-produced subcutaneous abscess did not vary with the causative organism.
(author's abstract)
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