J.Jpn. Surg. Soc.. 60(5): 851-873, 1959

---

STUDIES ON THE ESSENTIAL AMINOACIDS IN SURGERY

Results obtained by the method of microbiological assay confirmed the elevation of the plasma aminoacids levels in the patient with hepatic coma, Banti's syndrome and gastric cancer, and they showed that the tissue aminoacid level was greatly raised too. The latter has tendency to parallel to the degree of impairment of liver function, anemia and disturbances of plasma protein metabolism. No definite increase in the plasma aminoacid concentration was noted in the patient with gastric ulcer and gall stone. In general blood aminoacid concentration tended to decrease postoperatively while it increased in the patient with burns.
Regarding metabolism of free aminoacids in the patient applied with artificial kidney, the free aminoacids that showed marked elevation in the blood was found to decrease significantly following the dialysis through the cellophane tube (modification of Kolff type artificial kidney), and dog-lung (D-L type artificial kidney) as well as urea-N, electrolytes and A.D.H. The effects of cortisone, testosterone and thymus extract on the blood aminoacids concentration have also been studied and it was revealed that free aminoacids concentration in the blood elevated following the administration of cortisone and testosterone.
In an attempt to study digestion and absorption in the patient during recovery period, the blood from the portal vein has been sampled through the indwelling catheter and studied in comparison with peripheral venous blood. It was revealed that moderat amount of carbohydrate and protein are absorbed and retained in the body even at the first postoperative day. Notwithstanding, the patient was found to be unable to utilize effectively both carbohydrate and protein during the early convalescence period. For the purpose of the progressive nutritional rehabilitation of the postoperative patient the mixture containing concentrated suspension of essential aminoacids and the dry powdered aminoacids have been devised by the author and applied to the patients. This study demonstrates that beneficial clinical effect of such administration was evident with maintainance of positive nitrogen balance in the patients during the early convalescence period.
(author's abstract)

---

---

To read the PDF file you will need Adobe Reader installed on your computer.