[
Abstract]
[
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J.Jpn. Surg. Soc.. 60(5): 776-793, 1959
STUDIES ON WATER AND ELECTROLYTE METABOLISM IN INFANTS AND CHILDREN FROM THE SURGICAL VIEWPOINT
Studies were carried out on water and electrolyte metabolism in 64 infants and children hospitalized for surgical operation as well as in animals in an attempt to obtain information on water and electrolyte response to surgery. The present studies have been performed with a view to establishing standards, both quantitative and qualitative, for fluid therapy as part of the program for developing improved management of infants and children in pre- and postoperative periods.
Quite a large proportion of patients under the study proved to have a disturbed water and electrolyte metabolism on hospitalization. The fact that the majority of them were dehydrated and some of them had hypoproteinemia indicates the need for caution and prudence in administering fluid therapy prior to surgery.
In patients who had undergone minor operation water and electrolyte response to surgery was not serious, but there were oliguria, rise in specific gravity of the urine and disturbed electrolyte excretion in the urine. Patients who had undergone major operation or those who, though undergoing minor operation, had been in poor bodily condition were associated with oliguria combined with low specific gravity of the urine, showing a tendency to disturbed kidney function and consequently to accumulation of water and electrolytes in the body.
Water and electrolyte response to surgery varied from person to person according to the severity of the influence of operation as well as the kind and severity of the disease. Generally speaking, it was more marked in infants and children than in grown-ups.
The results of clinical and animal experiments show that the administration of a mixture of the equal amounts of Ringer's solution and 5% dextrose solution in a dose of 70 cc. per kg. of body weight and an addition of KCl, if needed, will be the best remedy to cope with hunger in pre- and postoperative periods.
(author's abstract)
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