J.Jpn. Surg. Soc.. 60(4): 663-678, 1959

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MECHANISM OF THE APPEARANCE OF CONVULSION FROM THE VIEW POINT OF THE EFFECT OF DRUGS WHICH SUPPRESS THE INDUCED CONVULSION WAVES

Mechanism of convulsions appeared in E.E.G. was investigated in this study. Cérébri isolé being used to prevent overlap of muscular manifestation on E.E.G., slow-acting INAH, quickacting Cardiazol and several inhibitory drugs were administrated to induce convulsions. Results are as follows :
Convulsion waves are originated in both cortex and subcortical nuclei.
Preponderance of convulsion waves induced by Ravonal, Auropan and Isomital are predominantly in the cortex more than in the subcortical nuclei. Viadril, Amipan and Pyrabital initiate thalamic action to induce cortical convulsion waves; that is, they act to cortex predominantly. Simple electric stimulation to cortex or subcortical nuclei does not induce convulsions. These agents might inhibit cortical action to intensify thalamic or subcortical action.
Observation in regard to these agents concurs their clinical use in this study .
(author's abstract)

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