J.Jpn. Surg. Soc.. 60(4): 615-631, 1959
CLINICAL AND EXPERIMENTAL STUDIES ON THE CHANGES OF PLATELET COUNT AND VASOCONSTRICTIVE ACTIVITY IN THE BLOOD AFTER BLOOD TRANSFUSION
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Prof. Katsura's Surgical Clinic, Faculty of Medicine, Tohoku University (Director: Prof. S-T. Katsura) Nobuo SAITO |
In order to clarify the cause of prolongation of bleeding time and for th treatment of it, these clinical and experimental studies were performed and the following results were obtained.
1) In proportion to the quantity of the transfused blood, thrombocytopenia appeared clinically and also experimentally in rabbit.
The infusion of sodium citrate seemed to aggravate this tendency.
2) The relation between the prolongation of bleeding time and the grade of thrombocytopenia was not proportional, and the cause of bleeding tendency could not be illustrated only by the thrombocytopenia.
3) Vasoconstritive activity in serum decreased after a transfusion of the stored blood.
4) Vasoconstrictive activity which was not only in plasma but also in platelet, decreased with lapse of stored time.
5) Decrease of vasoconstrictive activity after a stored blood transfusion was due to both the lowering of platelet count and the decreas of vasoconstrictive activity in the transfused platelets.
6) Existence of the antivasoconstrictive activity in plasma was clarified.
7) The antivasoconstrictive activity in plasma increased after the stored blood transfusion.
8) The important factors leading to progress of bleding tendency after massive blood transfusion are as follows: The first is lowering of platelet count, the next is decrease of vasoconstrictive activity in platelet, and th last is increase of antivasoconstrictive activity in plasma.
9) Cortisone and ACTH have a favorable effect to prevent the appearance of above-mentioned changes which lead to bleeding tendency.
(author's abstract)
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