J.Jpn. Surg. Soc.. 60(3): 512-522, 1959

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CHANGE OF BLOOD SUGAR CONTROLING SYSTEM IN TRAUMA

Studies have been made of change of blood sugar controling system in trauma such as head trauma, injuries of the chest, abdomen or extremities and burns, from the clinical point of view and animal experiments. Change in the liver was mainly observed.
The following results were obtained:
1. In early stage of trauma, severe cases showed higher level of blood sugar than the mild cases regardless to the types of trauma.
When the amount of glycogen in the liver decreased, there was always hyperglycemia. This can prove that the reason of hyperglycemia in early stage of trauma is hyper glycolysis in the liver and its excretion from the liver.
2. In every kind of trauma, frequency of finding abnormal glucose tolerance curve is higher in severe cases than mild cases. Most of cases in which parenchymatous liver damage exists showed also abnormal glucose tolerance curve and decreased capacity of storing glycogen in the liver.
3. Hypofunction of the homeostatic mechanism of blood sugar in the liver plays an important role based on its parenchymatous damage in change of blood sugar controling system in trauma.
(author's abstract)

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