J.Jpn. Surg. Soc.. 60(2): 195-208, 1959
STUDIES ON THE CORONARY CIRCULATION IN SURGERY Part II.
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Second Department of Surgery, Tokyo University School of Medicine (Director: Prof. Kimoto) Goro SAKAUCHI |
1) Coronary outflow and myocardial consumptions (oxygen, glucose, lactate and pyruvate) were significantly elevated over the control level during th period of ventricular fibrillation, but they came back gradually at the control level after the defibrillation.
Concerning myocardial carbohydrate metabolism during ventricular fibrillation, these were obtained almost same results by using either cross-circulation or artificial pumpoxygenator, but myocardial lactate consumption alone showed the inverse result between them. The cause was not evident.
2) There was a paralleled proportion between coronary outflow and mean arterial pressure in extracorporeal circulation by artificial pump-oxygenator.
There was a inverse proportion between coronary fraction and pump-flow, and the myocardial-systemic oxygen consumption ratio increased with the decreasing of pump-flow. Such results would represent the reaction of organism which kept the myocardial function as normal as possible when cardiac output was artificially decreased.
There was no disturbance in myocardial metabolism till 30 minutes after inflow occlusion of the heart during high flow perfusion, but the accumulation of pyruvate into the myocardium was found 30 minutes after inflow occlusion during low flow perfusion. It would be related to the limit of occlusion-time during low flow perfusion.
(author's abstract)
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