J.Jpn. Surg. Soc.. 60(1): 107-118, 1959

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SOME OBSERVATION IN PHOSPHOR METABOLISM OF HUMAN GASTRIC CANCER

Nineteen gastric cancer specimens obtained by gastrectomy have been studied in phosphorus contents and P³² uptakes.
Cancerous tissue and normal gastric mucous membrane are devided into 4 phosphorus fractions by Schneider's method. Phosphorus determination are carried after Allen's method. P³² determinations are performed by scanning with the liquid G-M counter (Kobe Kogyo) .
The results are as follows :
1. Of unit weight there is no difference in phosphorus contents and in P³² uptakes between cancerous tissues and normal gastric mucous membranes within 24 hours after P³² injection.
2. As for the phosphorus content in 4 fractions there is no significant difference between cancer and normal mucous membrane except in phospholipid fraction where phosphorus content of cancerous tissue indicates lower value than that of normal gastric mucosa.
3. Of P³² uptake in 4 fractions there is no difference between normal and cancerous tissues.
4. At first injected P³² are found chiefly in acid soluble fraction, then increase in phospholipid fraction and slight increase is observed in nucleic acid fraction simultaneously. But within 24 hours after P³² injection chief part of P³² uptake is in acid soluble fraction. This inclination are found both in cancerous and in normal gastric tissues.
5. At least within 24 hours after P³² injection there is little significance in diagnostic use of P³². Even more later than that time we have to give attention to diagnose gastric cancer by the increased P³² uptake.
(author's abstract)

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