J.Jpn. Surg. Soc.. 60(1): 63-76, 1959

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STUDIES ON THE CORONARY CIRCULATION IN SURGERY PART I.

The author investigated the effects of pentothal anesthesia, induced hypotension, experimental coronary artery occlusion and hypothermia on the coronary circulation and myocardial carbohydrate metabolism by coronary sinus catheterization or by cannulating into the coronary sinus under thoracotomy.
1) The changes in coronary circulation under both pentothal anesthesia and induced hypotension are very similar. Coronary flow and cardiac output decreased, but the change of the former is smaller than the latter. Both myocardial oxygen and glucose consumption decreased, but the decrease of the latter was more significant in pentothal anesthesia.
2) In experimental coronary artery occlusion, myocardial glucose extraction decreased in all cases twenty minutes after occlusion.
Myocardial lactate-and pyruvate extraction also decreased in progress and became negative gradually.
3) The author examined the effects on the coronary circu lation and myocardial carbohydrate metabolism under brain cooling and general hypothermia. In consequence, there was no great difference in either case. That ts io say, coronary flow decreased with the falling of body temperature, but its decrease was significant till 30°C in rectal temperature. Myocardial extraction did not show any change at 30°C in rectal temperature, but it was found that myocardial glucose extraction finally decreased at 26°C.
(author's abstract)

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