J.Jpn. Surg. Soc.. 59(10): 1711-1736, 1959

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EXPERIMENTAL STUDIES ON THE CHANGE OF THE FUNCTION AND TISSUES UNDER HYPOTHERMIC ANESTHESIA AND ITS RECOVERY STAGE

In an attempt to investigate the change of both function and tissues under hypothermic anesthesia and its recovery stage, we have done the experiment mainly on the effect of various drugs, specially of autonomolytic drugs, on rectal temperature. Secondly, hemorrhagic shock which occurred by performing the tests on liver and kidney functions has been mentioned. Thirdly, another experiment was undertaken by means of Melanin Smearing Method to evaluate the phagocytosis of granular leukocytes. Lastly, the observation was made upon the change of tissues in the autopsy caused by the super-hypothermia.
The results obtained are as follows :
1) When cooling and Chlorpromazine were employed, rectal temperature dropped down to 30°C about an hour after anesthesia, a stable result being noted while restoration of temperature also well stabilized.
2) When Meprobamate was injected intravenoulsy at a reduced speed prior to cooling, the onset of hypothermia to get 30°C rectal temparature became faster than one hour showing the utmost stability.
3) As regards th function of both the liver and kidney, the slight tendency of disturbance was noted at the rectal temperature of 30°C.
4) By cooling the rabbits down to rectal temperature of 30°C, we found a sudden death in many cases even by the blood loss of 15-20 cc due to the difficulty in restoring temperature. Whereas in the rabbits to which chlorpromazin was injected, the survival time was prolonged and the recovery was comparatively facilitated. From these findings, the inhibitory effect on hemorrhagic shock was obvious in the later group.
5) So far as we have demonstrated, phagocytosis seemed to increase during hypothermia, especially at the stage of restoring temperature. This fact has proved that both cooling and blocking drugs did not show any bad effect upon blood cells biologically.
6) In the observation on the change of tissues under the super-hypothermia, the remarkable congestion of blood cells was visible in most part of tissues, and the filling of blood was also noted in vessel where circulation was seemingly obstructed. The tissues of the heart, lung, liver, and kidney swelled respectively, in which vacuole appeared. Thus, the degeneration has been assumed to take comparatively a simple process.
(author's abstract)

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