J.Jpn. Surg. Soc.. 59(10): 1639-1644, 1959

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STUDIES ON SODIUM ALGINATE OF LOWER POLYMERIZATION, A PLASMA EXPANDER
III. CHANGE OF THE SERUM ELECTROLYTES LEVELS AFTER INTRAVENOUS INFUSION OF ALGINATE OLUTION

Changes in serum levels of Na, K, Cl, and inorganic P in human after infusion of alginate solution in dosage of 20cc per kg of body weight were investigated, together with the total Ca and the dialyzable Ca levels in dosage of 25 cc per kg of body weight. Changes in serum levels of Na, K, Cl in dogs, exsanguinated 20 cc per kg of body weight and the same dose of alginate solution was immediately infused, were also studied.
1) Changes of Na and Cl levels were inconsiderable extent, and K and P leveIs considerably decreased within the range of the physiologic variation, which was considered to be concerned with the metabolism of glucose which alginate solution contained.
2) Change of total Ca was negligibly small, and the dialyzable a somewhat decreased over the physiologic variation, though the clinical symptoms of Ca-ion deficit were never observed.
3) The solubility of calcium alginate was 2.94-3.08 mEq/l, which is higher than the dialyzable Ca level in serum. Therefore, the precipitation of calcium alginate never occurred in serum after infusion of alginate solution.
(author's abstract)

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