J.Jpn. Surg. Soc.. 59(10): 1592-1613, 1959

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THE EXPERIMENTAL STUDY ON THE EFFECT OF LOCAL USE OF THE ANTIBIOTICS ON THE PERITONEAL ADHESIONS (ESPECIALLY FROM THE STANDPOINT OF THE CAPILLARY PERMEABILITY)

An experimental study was performed on the adult rabbits in order to study the peritoneal adhesion after 6 hours after intraperitoneal administration of the antibiotics, i.e., Penicillin (PC), Dihydrostreptomycin (SM), Chloramphenicol-topical (CM), Tetracyn (TC) and Marphanil (ML).
Correlation between the capillary permeability and microscopic changes of serosa of the intestine and peritoneal adhesion was observed on the early stage of mechanical irritation or the experimentally induced inflammation intraperitoneally.
Result was as follows :
1) Capillary permeability increases for the use of the antibiotics (PC, SM, CM, TC, ML) intraperitoneally alone.
2) The increased capillary permeability and microscopic changes are the essential factor which cause the peritoneal adhesion.
3) No peritoneal adhesion occurs without microscopic change, without concerning about the capillary permeability. If there is no microscopic changes, increased capillary permeability is usually accompanied with the other intraperitoneal changes such as exsudation and bleeding.
4) When the capillary permeability and microscopic change are remarkable, peritoneal adhesion is showed absolutely.
5) The most important microscopic changes of the peritoneal adhesion are cell infiltration, fibrin excreation and hypertrophic change of connective tissue.
6) Local use of antibiotics and operative invasion are the essential two factors which were mentioned above for the induction of peritoneal adhesion. Therefore, the intraperitoneal administration of antibiotics must be avoided on the abdominal surgery and used generally.
(author's abstract)

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