J.Jpn. Surg. Soc.. 59(9): 1389-1402, 1958
EXPERIMENTAL AND CLINICAL STUDIES ON DLOOD-CEREBROSPINAL FLUID BARRIER II. BLOOD-CEREBROSPINAL FLUID BARRIER WITH SPECIAL REFERENCE TO CHANGES IN HEAD INJURIES.
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Department of Surgery, Fukushima Medical College, Fukushima. (Director: Prof. S. Endo) Yoshinori SUGAWARA |
Results thus obtained are as follow :
1) All subjects after any kind of head injury, showed elevation of the permeability of the blood-cerebrospinal fluid barrier. Of these subjects, those with cerebral contusion showed the highest degree of elevation, and those with a simple cranial trepanation only, the lowest degree, while moderate elevation was observed in those with their cortical tis ue electro-coagulated or with their ventricles filled with infused blood.
2) The permeability in the subjects with cerebral contusion showed an increase since the first day after the injury, with its maximum value in 3 to 5 days, and then a gradual decrease as far as its normal value. Similar tendency was also found in the subjects witr their ventricles infused with blood, or with their cortical tissue electrocoagulated.
3) Lowered absorption of cerebrospinal fluid was found in the subjects with brain contusion as well as in those with their ventricles infused with blood, and that in the former group an apparent increase in resorption was noted mostly in 5 days after contusion.
4) The above mentioned results assume that a rise in the permeability and a decrease in absorption of cerebrospinal fluid are chiefly attributed to the secondary changes following a hemorrhage in cerebrospinal fluid space, associated with altered permeability of the brain vessels.
5) The communicating hydrocephalus after head injuriy is supposed to be caused by both a hypersecretion and an aresorption of cerebrospinal fluid in its earlier stage, and chiefly by an aresorption only in its later stage.
6) The increased permeability are observed clinically in fresh head injury cases, most markedly in cases with hemorrhage in the cerebrospinal flluid space.
(author's abstract)
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