J.Jpn. Surg. Soc.. 59(8): 1290-1300, 1958
EXPERIMENTAL AND CLINICAL STUDIES ON BLOOD-CEREBROSPINAL FLUID BARRIER.
I. INFLUENCES OF VARIOUS DRUGS UPON BLOOD-CEREBROSPINAL FLUID BARRIER.
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Department of Surgery, Fukushima Medical College, Fukushima. (Director: Prof. S. Endo) Yoshinori SUGAWARA |
The conclusions are as follows :
1) The permiability of the barrier in normal rabbits proves to be equal to 2.75±0.17 percent on average.
2) Sulfuric atropine reduces the permeability. So this drug could have a favourable effect on the treatment of head injuries, preventing the cerebrospinal fluid tension from rising.
3) Hydrochloric pilocarpine causes a marked elevation in the permeability.
4) Adrenalin chloride has the permeability often raised yet sometimes also decreased.
5) Imidalin as well as Hexamethonium bromide raises the permeability ; any administration of these drugs might be problematical for a case of head injury in its acute phase.
6) Chlorpromazine as well as hydrochloric promethazine raises the permeability. So the winternization with these drugs for a case of head injury might not be recommendable.
7) Opium elevates the permeability, while phenobarbital reduces it. The latter might be a preferable drug as a sedative for a case of head injury.
8) An administration of large amount of water raises the permeability, and is supposed to elevate the cerebrospinal fluid tention. Therefore, this procepure might not be adequate in treating any case of head injury.
(author's abstract)
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