J.Jpn. Surg. Soc.. 59(7): 1184-1194, 1958

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STUDIES ON THE SENSITIVITY OF THE PATHOGENIC STAPHYLOCOCCI TO ANTIBIOTICS AND SULFISOXAZOLE, AND THE PHAGE-GROUPS OF THESE STAPHYLOCOCOCCI

The sensitivity to Penicill in (PC), Erythromy in (EM), Streptomycin (M), Tetracycline (ACM), Chlortetracyclin (AM), Oxytetraeycline (TM), Chlorarnphenicl (M), Novobiocin (Al), Bacitracin (BC), Leucomycin (LM), and Sulfisoxazole (Sulfa), and the phage-groups were studied on 100 coagulase-positive strains and 15 coagulase-negative strains of the staphylococci which were isolated from pus, sputum, nasopharyngeal swab, duodenal juice, blood, and urine during the period June 1956 to February 1957.
The increasing rate of the incidence of resistant staphylococi to antibiotics between 1951 to 1956 have been the following order : PC 50.1 per cent, SM 45.2 per cent (AM·TM) 15 per cent, CM 9 per cent.
One hundred coagulase-positive strains which were resistant over 66 per cent respectively to PC, SM, and Sulfa, were sensitive over 85 per ent repectively to Al, EM, BC, LM, CM, and ACM. These strains showed almost similar biological properties, i.e.. gelatin liquefaction, fermentation, hemolysis, and pigment production. Fifty-two per cent of these strains consisted of bacterisphage group III. (28 per cent) and a group which did not show lysis (24 per cent). The resistance pattern of these strains fell into the following order of increasing number : 26 per cent to PC • SM • Sulfa ; 15 per cent to PC • SM ; 11 per cent to PC; 8 per cent to PC • SM • ACM • Sulfa; 5 per cent to Sulfa; 4 per cent to PC • Sulfa; 3 per cent to SM ; 3 per cent to SM • CM • Sulfa.
Fifteen coagulase-negative strains did not show lysis, and had not constant biological properties.
The sensitive strains to PC or SM were found more frequently in the coagulase-negative strains than in the coagulase-positive strains.
(author's abstract)

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