J.Jpn. Surg. Soc.. 59(7): 1047-1074, 1958
EFFECTS OF GENERAL HYPOTHERMIA UPON THE SMALL VESSELS AND BLOOD FLOW AS SEEN IN THE MESENTERIES OF RATS.
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Department of Surgery, Branch Hospital, Faculty of Medicine, University of Tokyo Susumu HAYASHI |
A new plastic apparatus was designed for direct vision of the mesentery of rat. (Fig. I-VII) Several attentions were paid to the protection of the local intestine and mesentery from the mechanical and thermal injuries, and this apparatus satisfied these qualifications, especially with the experiments of general hypothermia. (Immersion method)
Part II. Hypothermia and Vascular Bed
1. General Refrigeration
Vasomotion is impaired or absent, blood flows through all capillary beds slowly, unrestrictedly and continuously. I call this phenomenon as condition like full tide. Epinephrine tests, topically applied, are slightly hyporeactive. Diameters of capillaries reveal relaxed dilatation. All of these changes are reversible with rewarming.
2. General Refrigeration with lytic cocktail
Condition like full tide is remarkable. Epinephrine thresholds are more hyporeactive than found in the refrigeration alone, though the dosis of the used lytic cocktail is small enough not to cause any change. This fact suggests the multiplying action of the lytic cocktail and refrigeration upon the mesenteric capillaries.
Part Ill. Hypothermia and Burn Shock
1. Burn Shock
The differences of the action of hypothermia and burn shock on the mesenteric capillaries are summarized as follows :
2. Burn During Hypothermic state
No effect particularly of burn ; blood flow is like full tide, and epinephrine tests are not hyperreactive.
3. Hypothermia Following Burn Shock
Blood flow like full tide, and epinephrine hyperreactivity is not proved. The longer the time elapsed before the hypothermia is applied, the more the stagnations and the capillary bleedings can be seen.
Effects of severe burn upon the mesenteric blood flow are thought to be masked by the characteristic phenomenon in the general hypothermia, then the blood flow like full tide maintains the peripheral circulation in satisfactory state and prevents tissue damage.
(author's abstract)
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