J.Jpn. Surg. Soc.. 59(2): 225-240, 1958
STUDIES ON THE TENSILE STRENGTH OF WOUNDS
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Surgical Department, Sagamihara National Hospital (Director: Prof. Soiti YANAGl and Dr. Tosio TAKAHUZI) Naoyosi ENOMOTO |
I have been discussed in this report the correlation between the surgical intervention and wound healing process.
About the biochemical studies of tissue, I have tried the fluid therapy and determined the tissue protein, electrolytes and water influenced by the wound healing.
1) The wound healing of the experimental animals has been affected by the extent of the surgical intervention, when those are treated by the same postoperative method.
2) The tensile strength of abdominal wall wounds, when Ringer's solution, 10% glucose, or polytamin and these mixture are administered as postoperative treatment in absolutely hungered animals, is counted.
Healing curve of Ringer's solution administered is better than that of starvation, 10% glucose is better than the Ringer's solution, and the administration of mixture is the most effective.
3) The water content of abdominal wall wound in the control increases after operation, and returns to normal level 4 days later. The vicissitudes of tissue Na and Cl follows as through the water.
4) The increased volume of tissue water and electrolytes in the experimental animals which were given Ringer's solution and in starvation, were not great at the immediate postoperative period compared with the control.
But in the cases that were layed in such state for a relativaly long time the wound healing was prolonged.
5) The vicissitudes of tissue protein and water have the great influence on the tensile strength. The repair of tissue collagen nitrogen has been found the first phenomenon in the process of healing.
6) Some clinical studies in ·anemic and hypoproteinemic patients have been discussed.
(author's abstract)
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