J.Jpn. Surg. Soc.. 59(2): 197-203, 1958

---

INFLUENCE TO THE BILE SECRETION OF ELECTRICAL STIMULATION OF THE MEDULLA

Forty-eight adult dogs were used. Anaesthesia was induced by Labonal injected intravenously in doses of 0.03 gr. per kilo body weight. Through a midline laparotomy, the gallbladder was extirpated and the pylorus was ligated in order to exclude the influence of gastric secretion, then polyethylen tube was inserted into the common bile duct to record the amount of bile secretion by means of a drop recorder.
The medulla was exposed by craniotomy and decerebellation. An unipolar electrode was inserted at random into various depth at various point upon the surface of the medulla and square wave pulse was applied (voltage 0.8V., pulse duration 10m. sec., frequency 50 c/sec., stimulating time 60 sec.). The distribution of points, stimulation of which resulted in an increase of bile secretion was found to be confined to the gray matter adjacent to the solitary fascicle, between the cranial end of the nucleus olivalis inferior and the obex. The distribution of points, stimulation of which resulted in a decrease of bile secretion was found to be restricted in ventro-lateral region of the reticular formation adjacent to the nucleus ambiguns between the cranial end of the nucleus olivalis inferior and the obxe. These results seem to indicate the antagonism between the dorsal and ventral parts of the medullary reticular formation which was alreaidy pointed out by Komatsubara, Kawashima, Higashiyama and Nishioka in regard to urinary, gastric, intestinal and pancreatic secretions.
(author's abstract)

---

---

To read the PDF file you will need Adobe Reader installed on your computer.