J.Jpn. Surg. Soc.. 59(2): 181-196, 1958

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STUDIES ON PHOSPHORUS METABOLISM OF GASTRIC CANCER USING RADIOISOTOPE P³²

The radioactivity, the phosphorus content and the rate of phosphorus turnover of gastric cancer and non-cancerous gastric mucosa were measured after the intravenous administration of P³². The specimens were obtained from 37 cases of benign gastric lesions and 34 cases of gastric cancers. At the same time, all of them were proved histologically. The following results were obtained.
1) There was no difference of radioactivity between the benign gastric lesions and the normal gastric mucosa. The P³² uptake ratio was less than 1.50 in all cases.
2) The radioactivity of the cancerous tissue was higher than the normal gastric mucosa. The mean value of the P³² uptake ratio was 1.70. But in 11 cases (32.4%) were less than 1.50.
3) The P³² uptake ratio of gastric cancer was remarkably lower than that of malignant tumor of the other organ, for example, the breast, skin, lung and brain.
4) There was no difference of regard to the phosphorus content between gastric cancer and normal gastric mucosa.
5) The rate of phosphorus turnover of gastric cancer, especially nucleic acid phosphorus showed conspiciously higher value than that of normal gastric mucosa. There was at least a 100% increase in DNA-P, RNA-P and lipoid P, whereas acid soluble organic P and residual phosphoprotein P turnover remaind unchanged.
6) The increased rate of phosphorus turnover was characteristic in the gastric cancer, and was not demonstrable in any benign gastric lesions.
(author's abstract)

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