J.Jpn. Surg. Soc.. 59(1): 126-138, 1958
EXPERIMENTAL STUDIES ON OXYGEN CONSUMPTION OF LIVER AND KIDNEY TISSUE AND ON THE INFLUENCE OF AUTONOMIC BLOCKING DRUGS IN SHOCK
|
Surgical Department, Keio University School of Medicine, (Director: Prof. Nobukatsu SIIIMADA) Osamu KONDO |
1) With increasing severity of shock from lethal doses of electric current (8,000-10,000 Joule) there is an increasing depression in te rate of oxygen uptake by liver slices. These changes may be largely a consequence of lack of oxygen. The tissue respiration of the kidney cortex was slightly depressed only in profound state of shock. But by passing sublethal doses of electricity, the rate of respiration of the liver and kidney slices were unaffected.
2) The rate of oxygen uptake by liver tissue was inversely related to the increase in blood amino-nitrogen and correlated with the blood pressure fall in shock.
3) Administration of hexamethonium bromide and Chlorpromazine maintained the normal levels of the rates of oxygen uptake by the liver and kidney tissue in vitro and in vivo experiments, as well as after the shock procedure. But Banthine had no snch effect.
4) The rates of oxygen uptake of liver slices in the bilaterally splanchnectomized and non-splanchnectomized groups of rabbits exhibited no depression after the shock procedure, while that of the kidney slices were slightly depressed in both groups.
5) Chlorpromazine markedly depressed the rate of oxygen consumption of brain tissue homogenates in vitro, but not in vivo. Hexamethonium bromide did not affect the brain oxygen consumption at all in vivo or in vitro.
6) The author believes that controlled hypotension, artificial hibernation and bilateral splanchnectomy, followed by lethal doses of electricity, probably stabilizes the blood flow of the liver and kidney, and also protects the tissues by rending them resistant to anoxia.
(author's abstract)
To read the PDF file you will need Adobe Reader installed on your computer.