J.Jpn. Surg. Soc.. 59(1): 94-104, 1958
EXPERIMENTAL STUDIES ON RECURRENCE OF CARCINOMA RESECTED CONSERVATIVELY
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1st Department of Surgry, Chiba University School of Medicin (Director: Prof. Naotsugu KAWAI) Masayoshi SUGIMOTO |
1. Result of transplantation using a rice-grain-sized seeds was positive in 85% and negative 15%.
2. In positive cases of transplantation conservative resection was performed and 3 or 5 rice-grain-sized carcinomatous tissue was left. The rate of recurrence was 91 and 96% respectively. In such cases, the tumor cells showed extensive proliferative nature in early stage after operation, but proliferation of connective tissue around the tumor was weak. On the contraly, when 1/2, 1 or 2 rice-grain-sized tumor tissue was left, the rate of recurrence was 40, 57 or 72% respcetively. In such cases, the tumor tissue degenerated during several periods after the operation, but proliferation of connective tissue around tumor tissue was very strong since early stage after operation.
In short, proliferation of the connective tissue around the reamaining tumor tissue was observed after conservative resection. This is a reaction of tissue cells of the living body against tumor, namely anticarcinogenic action of the living body. This action is supposed to be inhibiting or preventing the development of the remaining tumor tissue more or less, and the action is more marked when the remaining tissue is smaller.
3. Accordingly, when surgical treatment of malignant tumor is performed too extensive resection without respect to general condition must be avoided.
In cases of poor risk patient, conservative resection is rather recommended, and improvement of general condition, i.e., improvement of anticarcinogenic action and disappearance of tumor must be expected.
(author's abstract)
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