J.Jpn. Surg. Soc.. 59(1): 36-62, 1958
THE INFLUENCES OF ARTIFICIAL HIBERNATION IN THE LIVER
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The 1st Department of Surgery, Nagoya University School of Medicine (Director Prof. Yoshio HASHMOTO) Taichiro SATO |
I. Remarkable hepatic complication has been found in no case of 259 patients applied artificial hibernation, pharmacological hibernation and "potenzierte Narkose". Liver glycogen increased or decreased during the cooling period of artificial hibernation and hypothermia, while it decreased in usual anaesthesia. But it decreased rapidly during rewarming in all cases. When ether being used, liver glycogen did not increase during artificial hibernation. Bloodsugar level fell with the fall of body temperature during artifi cial hibernation and hypothermia, but it tended to recover at 30°C of rectal temperature. The hypoglycemia during hypothermia was severer than that in artificial hibernation. There was hypoglycemia during artificial hibernation even when ether was used. Judging from hepatic arterio-venous bloodsugar difference, admit of sugar in the liver was thought during artificial hibernation and release of sugar during pentothal anaesthesia. When ether was used, admit of hepatic circulation occurred at the rectal temperature below 30°C.
II. The existence of hepato-intestinal circulation of chlorpromazine in vivo was thought from the facts that chlorpromazine level in the blood was higher in the mesenterial vein than in the hepatic artery of vein and chlorpromazine was excreted into gall.
III. The action of cocktail was more effective in less amount than those without injured liver. Destruction ability of chlorpromazine in the injured liver decreased clearly. When with injured liver deeper and longer anaesthesia was thought about by the same dosage of the cocktail as compared with the normal one. But, even if the same dosis of chlorpromazine as in normal animal was given to the animal with injured liver, no damage caused histopathologically.
IV. Intravenous rapid administration of chlorpromazine caused convulsion. Degeneration and congestion were found diffuse in the liver, kidney, Langerhans' island of the pancreas and suprarenal gland after administration of a large amount of the cocktail, and findings like hepatitis and renal toxication were observed. FAD may be antagonist against chlorpromazine.
Remarkable findings about the influences of artificial hibernation on the liver were obtained from investigations on both sides of the physio-pathology in artificial hibernation and of the pharmacology of chlorpromazine.
(author's abstract)
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