J.Jpn. Surg. Soc.. 59(1): 14-35, 1958

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AN EXPERIMENTAL STUDY ON THE ALLERGIC CHANGES IN THE STOMACH AS PROVOKED BY REINJECTION INTO THE STOMACH WALL

In this paper the author treats of his studies on the extent of digestion of antigen substance in the stomach, local difference of allergic reaction in digestive tract, Arthus' phenomenon in the gastric wall under exclusion of action of hydrochloric acid of the stomach.
Results.
1. Egg albumin is digested in mixture solution of hydrochloric acid and pepsin in a condition possibly resembled with that in the human stomach. Then the extent of digestion is determined with precipitation reaction, and the results show that egg albumin, though undergoes considerable digestion, secures its antigenicity.
2. Tissue reaction by submucosal Arthus' phenomenon is studied in the several parts of intestinal tract in dogs and rabbits, which were previously sensitized with pig serum. In both dogs and rabbits, the mucosa of pyloric glandullar region reacts far stronger than the mucosa of the fundic glandullar region, the duodeunm reacts much weaker, and the jejunum shows no reaction. Thus the local difference of the pathologic changes of tissue is clearly demonstrated.
3. The development of erosions and ulcers is seen in the mucosa of pyloric glandullar region of sensitized dogs with pig serum, when the antigen is reinjected. Morphologically the changes are due to either inflammation or hemorrhage.
4. The author's provocation method differs from the method employed in clinical use, but the findings obtained through such experiment are also of significance in the fundamental study of allergic changes in the gastrointestinal tract.
(author's abstract)

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