J.Jpn. Surg. Soc.. 58(11): 1838-1848, 1958

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CLINICAL AND EXPERIMENTAL STUDIES ON THE OCULAR SYMPTOMS INDUCED FROM THE LENTICULAR NUCLEUS.

In 1952, Prof. Ozawa reported the lenticotomy upon the extrapyramidal disorder cases including epilepsy and Little's disease, etc. brought better improvement clinically. On this operation we often experienced many a case showing ocular signs accompanying with the invasion of the lenticular nucleus. Thereafter, the author studied these ocular phenomena employing electrical stimulation and chemical lesion upon this nucleus clinically and experimentally.
Results obtained are as follows :
1) Clinical results
On 79 extrapyramidal disorder cases, the author attempted to stimulate the lenticular nucleus electrically. These cases were trepanated under local anesthesia. As a results the author observed pupillary dilatation on 11 cases, hippus on 7, pendular movement of eyes on 5 and nystagmus on 5 cases. These symptoms were bilateral and lasted for 5 sec. to 3 min.
By the chemical lesion of the nucleus, administrating diluted sublimate solution, the author observed pupillary dilatation on 9, hippus on 16, pendular movement of eyes on 14, nystagmus on 11, and deviation of eyes on 15 cases among 126 patients. These signs also lasted for 30 sec. to 4 days.
2) Experimental results
The stimulation was carried out adopting the electrostimulator bipolarily into the lenticular nucleus of the dog or the cat. The experimental data lead us to conclude a criteria that the induction of the pupillary dilatation from this nucleus has such a optimal range as follows :
Voltage 8―15 V.
Frequency 50―60 c/s.
Duration 5msec.
The nicotinization of this nucleus, admistrating a small amount of 20% nicotine sulfate solution, caused pupillary dilatation temporarily, but, it makes the following electrical stimulus unable to introduce above described phenomenon. Thus this pupillary dilatation which was induced electrically as above mentioned is considered to be originated from this nucleus. Followingly the mechanism of the pupillary dilatation was investigated experimentally and the author found that the excision of frontal cortex and the destruction of hypothalamus had no relationship on this phenomenon. The author found remarkable dilatation on this mechanism by the stimulation of this nucleus after the cervical sympathectomy more clear than after the transsection of the oculomotor nerve.
As a conclusion, the pathway of this pupillary dilatation induced by the stimulation of the lenticular nucleus is owed to the reciprocal innervation of the oculomotor nerve and the cervical sympathetic ganglion and, especially, the oculomotor nerve acts mainly among above two routes.
(author's abstract)

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