J.Jpn. Surg. Soc.. 58(10): 1603-1618, 1958
STUDIES ON THE MESENTERIC CAPILLARY CIRCULATION, ESPECIALLY IN THE EXPERIMENTAL INTESTINAL OBSTRUCTION.
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First Department of Surgery, Tokushima University School of Medicine (Director: Prof. S. TAKITA) Hitoshi OKADA |
The experiments were made on the rat and rabbit with and without experimental obstruction of the intestine. For a better microscopic observation of the mesenteric capillaries, a modified Zweifach's horseshoeshaped moist chamber method was employed.
The red cell stream in the capillaries was recorded both by ordinary microscopic photography and by 16mm high speed cinematography.
The results are summarized as follows :
1) In rabbits with intestinal obstruction, the average flow rate of the red cells is 593.5μ (1912) per minute in the arteriole, 489μ (1018) in the distributing capillary, 363μ (727) in the net capillary, 392.5μ (879) in the collecting capillary and 395μ (1011) in the venule. The average values in normal rabbit are given in parentheses.
2) The average diameters of the mesenteric capillaries immediately above the obstruction is 23μ in the arteriole, 18μ in the distributing capillary, 15.3μ in the net capillary, 25.3μ in the collecting capillary and 37.6μ in the venule.
3) The minimal effective concentration of epinephrine (adrenalin test) to induce contraction of the mesenteric capillary was 1/8 10-5 to 1/2 10-5 at the portion immediately above the obstruction and 1/8 10-5 to 10-5 immediately below the occlusion, the normal being 1/6 10-6 to 1/3 10-6.
4) In normal intestine, the segmentation or peristalsis are accompanied by a transitory sluggishness of the capillary stream of the mesentery. In the intestinal obstruction, the effect of respiratory movement on the capillary stream becomes conspicuous.
In the intestinal spasm, moreover, the stream arrests completely and the red cells gather themselves in groups with empty space along the capillary.
With the recovery from the spasm, the circulation is restored.
This is most distinctly demonstrated in the mesentery immediately above the obstruction but is not distinct at the part distant from the obstruction.
5) Sluggishness of the red cell flow, conspicuous effect of the respiratory movement upon circulation and the tendency to hemorrhage of the mesenteric capillary are more marked immediately above the site of obstruction and not observed at the distant part above the level of obstruction.
(author's abstract)
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