J.Jpn. Surg. Soc.. 58(10): 1567-1589, 1958
STUDIES ON THE PLATELET AND THROMBOPLASTIN
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2nd Surgical Department, Osaka University Medical School (Director : Prof. M. Kuru) Enryu NAKAI |
1) The platelet does not liberate an appreciable amount of active thromboplastin by its destruction. Cephalin can substitute for the platelet in the generation of thromboplastin. The co-existence of the plasma thromboplastin factors, Ca#, and the platelet (or cephalin) results in the generation of active thromboplastin apart from the generation of thrombin. Although a thromboplastin generation mixture is lacking in Ca#, it produces at least a forerunning change which, if added by Ca#, will develop into a rapid generation.
2) The platelet liberates a cephalin-like substance when it is subjected to such changes as adhesion, agglutination, or disintegration.
3) The platelet or cephalin acts as a limiting factor in the generation of thrombo plastin. The amount of the platelet or cephalin is correlated with that of the generated thromboplastin.
4) The cephalin-like activities of a platelet suspension is less resistant to heating than crude cephalin.
5) The enhancing activities on thrombin generation reactions of the platelet suspension are similar to those of the plasma accelerator globulin, the former being more thermostable than the latter.
6) When the amount of antihemophilic factor (AHF) contained in the thromboplasin generation system decrease to an amount slightly less than the normal value, the amount of the generated thromboplastin comes to be considerably reduced, and when the amount of AHF further decreases, the velocity of the thromboplastin generation becomes markedly low.
7) A decrease in PTC (Plasma Thromboplasin Component) retards the generation of thromboplastin, and the amount of the generated thromboplastin is also reduced.
8) Of 5 suspected cases of hemophilia 4 prove to be classical hemophilia and 1 PTA (Plasma Thromboplastin Antecedent) deficiency.
(author's abstract)
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