J.Jpn. Surg. Soc.. 58(10): 1549-1566, 1958
EXPERIMENTAL STUDIES ON THE INHIBITING EFFECT ON HEMORRHAGIC SHOCK DUE TO ARTIFICIAL HIBERNATION AND CONTROLLED HYPOTENSION
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Surgical Department, Keio University School of Medicine (Director: Prof. Nobukatsu SHIMADA) Keijiro ARATA |
Through these observations, we have also demonstrated that the blockade of the autonomic nervous system influences some preventive effects on shock.
In further studies the following results were obtained by the author in application of artifical hibernation and controlled hypotension to hemorrhagic shock in dogs.
1) Both artifiical hibernation and controlled hypotension have the shock preventing ,effect, as to be proved by the prolongation of survival time and inhibition of Amino-N, CO2 and pH changes in the arterial blood.
2) Chlorpromazine and hexamethonium ammonium bromide play an important role in the mechanism, whereas Banthine, a parasympathicolytic drug, has no effect. That is to say, sympathetic blocking is considered to be effective in shock prevention.
3) As splanchinectomy is effective, the blocking of the splanchnic area is also significant.
4) Controlled hypotension and hypothermia are considered to have supplementary eftect on shock prevention.
(author's abstract)
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