J.Jpn. Surg. Soc.. 58(9): 1406-1423, 1957

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STUDY ON CHANGE OF THE BRONCHIAL MUCOUS MEMBRANE IN THE CHRONIC NON-SPECIFIC INFLAMMATORY FOCUS FROM THE VIEW POINT OF THE PRECANCEROUS BACKGROUND

In order to clarify the influence of non-specifiic inflammatory change of the lung on the bronchial mucous membrane from the view point of the precancerous background, resected lungs of 52 cases of chronic pulmonary infections and 24 cases of the abnormal bronchial dilatation were studied; and the following conclusions were obtained.
1) Through there were many varieties of reactions of the bronchial mucous epithelium against chronic non-specific inflammations, these changes could be classified as follows from the morphological point of view : Cylindrical Epitherial Proliferation, Squamous Cell Epitherial Metaplasia, Metamorphological Proliferation, Adenoid Metaplasia and Cancerous Change.
2) These changes except carcinomatous change were closely connected to the change of inflammatory picture. In cases of mixed inflammatory changes in which cellular infiltration and marked proliferation of the inflammatory granulation were observed, those changes appeared most remarkably as a result of the proliferation of the basal cell and with the disappearance of inflammation their appearance also decreased.
3) Epitherial proliferation of the granulation was most frequently observed on the bronchial wall and squamous epithel was mainly observed on the wall of cavity. Adenomatous metaplasia was observed in the focal parenchyma as the mucous epithel of the peripheral bronchus which is buried in the focus. Rare metamorphological proliferation was observed as a partial phenomenon of the metaplasia of the squamous epithel. However, those proliferative changes cannot be directly connected to the carcinogenesis.
4) Primary picture of the peripheal type of the pulmonary carcinoma which is thought to be clearly originated from one of the adenomatous metaplasia of the fibrous focus, was really detected in the specimens. Though the finding mentioned above is a very small phenomenon, it is an important factor which practically supports the possibility of the development of cicatrical carcinoma in the lung.
(author's abstract)

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