J.Jpn. Surg. Soc.. 58(7): 1077-1096, 1957
THE EXPERIMENTAL SYUDY OF THE VASCULAR DISTURBANCE IN THE PEPTIC ULCER (SETTING THE VITAL MICROSCOPIC OBSERVATION OF THE SHAY-ULCER IN CHIEF)
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Surgical Department, Osaka City University Medical School (Director: Prof. H.Sawada) Yosohiro NAKAJIMA |
2) The vascular system of rat's fore stomach has the same form and function as those in the other visible regions. The vascular system are more influenced by fasting than distending, and show the congestion and production of the vascular-net after some continuous fasting.
3) There are remarkable stasis, venous dilatation, arterial spasms and hemorrhage in the vascular system of the Shay-rat's stomach, but the great part of them are the secondary disturbances followed the ulcer formation.
4) The continuous observations of the ulcer formation processes were performed. These observations show that the ulcer begins from the primary vascular disturbance, local stasis of the venule, and spot or fleck-like hemorrhage, and enlargement of the ulcer follows the repeating hemorrhages. These typical mode of the ulcer formation does not appear again at the insertion of the artificial gastric juice, but reappear by the insertion of acetylcholin added artificial gastric juice. The time for ulcer formation after pyloric ligation become rapid by the prolonged fasting.
5) It is showed by the various accesory experiments that these primary vascular disturbances, stasis and hemorrhage are neuro-vascular origin, and ulcerated by the peptic activity of gastric juice. Morphology of the hemorrhage and the ulceration in the rabbits stomach mucosa are traced with Benzidine stain and the other. Ulcer formation of the rabbits stomach are analogous with those of Shay-rat.
(author's abstract)
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