J.Jpn. Surg. Soc.. 58(7): 1007-1022, 1957

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THE EXPERIMENTAL STUDY OF THE BILE ACID METABOLISM

The periodic changes were studied of various bile acids which were extracted in the hepatic bile of a rabbit, whose left-side adrenal was removed, and whom the cholesterin and bile acid of kinds were injcted through the auricular vein.
The followings are the significant reactions although further experiment will be needed.
These are;
1. The lack of correlated activity of the choleretic action and the cholagoga action :
2. The disturbance of the cholic acid-dehydrocholic acid (C₃-Keto bile acid) metabolism by one-half strong:
3. No disturbance of dehydrocholic acid metabolism, and
4. The transformation of the cholesterin-cholic acid metabolism by thesupp lementaion of cholesterin when the hormone declines.
These experimental results above mentioned will be explained easily when their activities are based on the cholic acid- desoxycholic acid metabolism theory.
(author's abstract)

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