J.Jpn. Surg. Soc.. 58(4): 603-609, 1957

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STUDIES ON THE PERIVASCULAR SPACE (REPORT V.) PATHOLOGICAL STUDIES IN EXPERIMENTAL HEAD INJURIES (PATHOLOGIC CHANGES IN THE PERIVASCULAR SPACES)(PART 2)

Attemps were mad to produce experimentally, under sterile conditions, injury of the cerebral parenchyma with depressed fracture of the skull. Use was made of healthy rabbit anaesthetized with ether after receiving two injections of a mixed solution of chlorpromazine and prethiazine. They were devided into two groups, of which the one were killed one month thenceforth, the other two months thenceforth.
The present author made histopathological studies of the traumatic brain, chiefly the perivascular space.
1. The meninges at the site of injury developed arachnoiditis, of which the first type developed incrassation and proliferation of the arachnoid, the second type proliferation of the trabecular connective tissue.
2. The cerebral parenchyma at the site of injury developed regressive changes such as increase of glia cells and fibers, and multiplication of the microglia and astroblasts.
3. Regressive changes, viz., multiple demyelination were observed in the whole part, mostly in the injured part of the brain.
4. A slight creation of vessels of the brain was observed as one of regressive functions. Formation of the perivascular space was not recognized at the site of considerable proliferation of the glial tissue. At the junction of the site of injury with the normal part of the brain was observed the perivascular space with deformity and enlargement.
5. Partial enlargement of the subarachnoid space was observed.
(author's abstract)

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