J.Jpn. Surg. Soc.. 58(4): 595-602, 1957
STUDIES ON THE PERIVASCULAR SPACE (REPORT Ⅳ.) PATHOLOGICAL STUDY IN EXPERIMENTAL HEAD INJURIES (PATHOLOGIC CHANGES IN THE PERIVASCULAR SPACES)(PART 1)
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Department of Surgery I., Hiroshima University Medical School (Director: Prof. R. Uemura) Takeo YAMAMOTO |
Morbid changes caused by various traumatic injuries were studied in the first group. While morbid changes with the passage of time were pursued, under almost same conditions as above mentioned, in the second group.
Histopathological studies were made of these traumatic injuries.
1. The larger hemorrhages into the cerebral parenchyma and brain stem occurred in increasing order of morbid changes due to trauma. Hemorrhages into the cerebral parenchyma occurred corresponding to the predilection place, the anterior base of the brain, of traumatic injury.
2. Morbid changes were observed in the vessels and the perivascular space.
In comparatively minor injury, the congestion of small vessels and capillaries was recognized, and the perivascular space was narrower.
In major injury, a transudation of blood, mainly erythrocytes, into the perivascular space was seen, until it showed the manifestation of transudative hemorrhage. Due to the rupture of the arachnoid, the internal wall of the perivascular space, as well as the wall of the vessels, hemorrhage was limited within the perivascular space. Farthermore in more sever injury, hemorrhage per rhexin into the cerebral parenchyma was caused by the rupture of the pia mater, the external wall of the perivascular space, together with the rupture of those above mentioned; especially of small veins and capillaries.
In the cerebrospinal fluid, encephalovessel and cerebral parenchyma, mechanically abrupt changes were caused due to traumatic injury. It may be that these changes developed the manifestations, as above descrived, in the perivascular spacs. The perivascular space may serve buffer action to protect the cerebral parenchyma from the static external force.
3. In the cerbral ventricle were found comparatively remarkable changes; destructive or regressive changes such as destruction or ablation, multiple formation of ependyma and subendymal gliosis.
(author's abstract)
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