J.Jpn. Surg. Soc.. 58(3): 452-459, 1957

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STUDIES UPON SODIUM ALGINATE OF LOWER POLYMERISATION, A PLASMA EXPANDER
PART 3: SOME FACTORS ON THE DEPOLYMERISATION OF SODIUM ALGINATE

The change in the rate of depolymerisation of sodium alginate due to the difference of its solvent was followed by means of flask with refluxed condenser. And the following results are harvested.
1. The decrease of viscosity was slight in sodium alginate dissolved in 0.9% saline solution ot distilled water heated up to 100° C., but when solvent was 5 % Dextrose there was rapid decrease of viscosity observed.
2. There were comparatively marked shift of pH to acid side in sodium alginate plus 5% Dextrose heated up to 100°C. And the shift of pH was slight when sodium alginate was solved in 0.9% saline solution.
3. Sodium alginate in 5% Dextrose, when its pH kept approximately neutral by means of buffer solution, showed even in 100°C. slight decrease in viscosity, but when its pH was kept to acid side, there was marked decrease in viscosity.
4. The shift of pH to acid s ide may be considend one of causes in the decrease of viscosity in sodium alginate solved in 5% Dextrose and heated up to 100° C.
(author's abstract)

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