J.Jpn. Surg. Soc.. 58(3): 443-451, 1957

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STUDIES UPON SODIUM ALGINATE OF LOWER POLYMERISATION, A PLASMA EXPANDER
PART 2: STUDIES OF THE EFECT OF SODIUM ALGINATE OF LOWER POLYMERISATION ON BLOOD PRESSURE

Sodium alginate, the degree of the polymerisation being kept constant (Intrinsic viscosity about 0.072), prepared in solution of different concentration 0.6%, 0.5%, 0.4%, and 0.3% respectively, was given intravenously in rabbit subjected to blood letting in dosis of 20 c.c. per kg. of body weight. And the effect of these solutions on the elevation and maintenance of blood pressure was compared with that of 5% Dextrose, Algin, Glyco-Algin, Dextran and Periston.
1. The 0.6%, 0.5%, and 0.4% solution of sodium alginate of lower polymerisation are equally well with Algin or Dextran in the elevation and the maintenance of blood pressure.
2. The 0.3% solution of sodium alginate of lower polymerisation, commercialised Glyco-Algin and Periston are inferior to these solutions above mentioned in the maintenance of blood pressure.
3. From the results of the extensive studies made in the Tomoda's Surgical Clinic, 0.4% solution of sodium alginate of lower polymerisation can be concluded as a recommendable plasma expander which satisfies every requirement.
(author's abstract)

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